Synthesis, Characterization and Biological Evaluation of Novel 2-Alkyl-imidazo[2,1-b]thiazol-3-one

Authors

  • Raju Kharatkar  Department of Chemistry, Shri Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, Rajasthan, India.
  • Kartik Vyas  Sheth L. H. Science College, Mansa, Gandhinagar, Gujarat, India.

Keywords:

Imadazone, Thiazole, Imidazo-Thiozole, Antibecterial, Antifungal

Abstract

A series of novel Imidazo[2,1-b]thiazole-3-one derivatives substituted at 2-position with several alkyl and aryl group were synthesized, characterized, and their antimicrobial as well as antifungal properties were evaluated. . These compounds were synthesized by formation of sulphide bond in protic solvent using strong base, such as potassium hydroxide or sodium hydroxide, followed by cyclization in presence of mild acid such as silica get or acidic resin. The compounds synthesized were characterized using FTIR, 1H NMR and mass spectroscopy. The compounds synthesized were screened for in vitro activity against S. aureus, E. coli, P. aeruginosa, S. typhimurium, F. oxysporum and A. alternata. Some of these compounds exhibited moderate to good activity, whereas some were found inactive, against pathogens being evaluated.

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International Journal of Scientific Research in Science and Technology

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Published

2017-01-30

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Volume 3, Issue 1, January-February-2017

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Research Articles

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How to Cite

[1]
Raju Kharatkar, Kartik Vyas, " Synthesis, Characterization and Biological Evaluation of Novel 2-Alkyl-imidazo[2,1-b]thiazol-3-one, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 3, Issue 1, pp.876-685, January-February-2017.